EXAMPLE PROCESS CHALLENGES IN NANOSUSPENSION FORMULATIONS AND APPLICATIONS - poster
R Palaparthi1,2, Barnamala Saha3
1 Anagha Consultants, Bhagyanagar 500050, INDIA
2 Anagha Consultants LLC, Hockessin DE, USA
3 Amity School of Engineering and Technology, Amity University Haryana, INDIA
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Specialty inks and some niche pharma formulations can be presented in the form of suspensions of nano particles. When they are prepared in a top down approach, larger size particles are milled to the required size using appropriate energy input, in the presence of surfactants for surface stabilization. Such suspensions are either used as is or subjected to downstream process steps for use in final applications. Characteristics like particle size distribution, shelf-life, and rheology impact their performance during the end-use. For a given chemistry, the preparation method of the suspension, batch sizes, and the conditions of the downstream process steps can significantly impact the performance of the finished products.
This poster discusses a couple of example challenges faced in a real-world scenario related to getting a reproducible nanosuspension product at one scale and scaling it up. It shows how structured approaches characterizing the materials, process, and understanding the underlying materials-process interactions, help address these challenges and achieve consistency in the finished product performance. Attention to such details during early stages of process development in an industry can result in significant cost-savings downstream.